Center for Traditional Medicine

CTM Curated Research

Shatavari and Female Reproductive Health: An Ayurvedic Approach to Hormonal Regulation and Menopausal Symptoms 

Shatavari (Asparagus racemosus) is an Ayurvedic herb used in herbal medicine for hormonal balance and stress adaptation. Although traditionally said to foster attachment and affection, Shatavari root extract is now more commonly recognized for its phytoestrogenic activity. It contains phytoconstituents, including steroidal saponins (Shatavarins), which modulate the function of estrogen receptors, gonadotropin levels, and antioxidant and anti-inflammatory activity. These potential health effects highlight significant promise for contemporary hormonal and reproductive health research, enhancing the clinical evidence base for this popular Ayurvedic herb.

Asparagus racemosus (Shatavari) with lemon slice.
Asparagus racemosus (Shatavari) with lemon slice. Photo by KamranAydinov on Magnifix.

Shatavari originated in Ayurveda, the traditional system of Indian medicine, and is native to India and the Himalayan region. Its history is first documented in foundational Ayurvedic scriptures such as the Charaka Samhita and the Sushruta Samhita. In Sanskrit, “Shatavari” translates to “she who possesses a hundred husbands,” symbolizing its association with femininity and reproductive prosperity. Ancient Sanskrit texts recommend Shatavari supplementation to support menstruation, boost fertility, and increase break milk production in nursing mothers. These texts also detail its long-standing use in enhancing longevity and vitality.

Today, Shatavari continues to evolve within modern medicinal practices as herbalists and researchers explore its safety and efficacy for traditional and integrative applications. Historical documentation and recent findings illustrate Shatavari’s potential to make a meaningful impact for women’s health. 

Research in female reproductive health highlights the historic underrepresentation of women in the scientific sphere. As inclusion in clinical studies expands for female reproductive and hormonal health, interest in herbal alternatives to pharmaceutical interventions has also increased. Shatavari represents a growing component of the knowledge base surrounding women’s health, particularly regarding menopausal and hormonal irregularities. The following five studies provide compelling evidence for the positive effect of Shatavari in premenopausal, perimenopausal, and postmenopausal women. 

The first study employed an eight-week, double-blind design to evaluate the efficacy and safety of Shatavari root extract (SHT) alone and in combination with Ashwagandha root extract (ARE) in women experiencing menopausal symptoms. The 135 participants, women aged 45-65 years old, were divided evenly among three groups: SHT, ARE-SHT, and a control group. The effects of the herbal interventions were measured using the Menopause Rating Scale (MRS) and the Menopause-Specific Quality of Life Questionnaire (MENQOL). Researchers observed significant improvement in MRS scores in the SHT and ARE-SHT groups, although the ARE-SHT group demonstrated especially notable effects. Additionally, MENQOL reports improved, suggesting enhanced mood and self-esteem-related outcomes. The study illustrated the safe and promising effects of Shatavari root extract in menopausal women and suggested the potential for additional overall health benefits when combined with Ashwagandha root extract.

The second study reviewed existing research regarding the hormonal effects, reproductive benefits, and stress-modulating properties of Shatavari root. Supplements were administered in various forms, including capsules, powders, and tinctures. The review summarized studies reporting significant relief from menopausal symptoms, improved reproductive outcomes in women with irregular cycles and hormonal disorders, increased lactation in postpartum women, and reduced oxidative stress. This article refined current findings and called for the integration of traditional Ayurvedic knowledge with contemporary scientific research, advancing upon our understanding of female reproductive health, hormonal regulation, and management of conditions such as Premenstrual Syndrome (PMS), Polycystic Ovary System (PCOS), and menopause.

The third article investigated the effects of dietary supplementation with Shatavari and Ashwagandha extracts, examining their individual and combined influence on menopausal symptoms, vascular dysfunction, bone turnover, and inflammatory and oxidative stress markers in postmenopausal women. The study enrolled women aged 40-55 years old in a double-blind trial in which participants received one of six treatment combinations: placebo, two different doses of Shatavari extract, two different doses of Ashwagandha extract, or a combination of both supplements. Results were measured after 24 weeks using MENQOL scores, bone mineral density and bone turnover markers (BTMs), and Reflection Index (RI). Additional measurements included inflammatory and oxidative stress markers and evaluations of supplement safety and tolerability. Researchers found that all supplemented groups demonstrated significant, dose-dependent decreases in MENQOL and RI compared with the placebo group. Additionally, the supplemented groups showed significantly reduced bone turnover and resorption. Inflammatory and oxidative stress markers also decreased, correlating with reduced estrogen deficiency-related inflammation in postmenopausal women. These findings suggest that daily supplementation with Shatavari or Ashwagandha extracts may reduce menopausal symptoms and vascular dysfunction while improving overall health. 

The fourth study evaluated the safety and efficacy of CL22205, a standardized Shatavari root extract, in managing perimenopausal symptoms in 50 women experiencing mild to moderate climacteric symptoms. Participants received either 200 mg/day of Shatavari extract or a placebo over 120 consecutive days. Measured outcomes included the Menopausal Rating Scale (MRS), Hot Flash Weekly Weighted Score (HFWWS), Menstrual Symptom Questionnaire (MSQ), Integrative Medicine Patient Satisfaction and Outcome Scales (IMPSS & IMOS), and other general measures of reproductive and hormonal health. Participants reported significantly reduced MRS scores and HFWWS scores compared with both placebo and baseline measurements following the treatment period. Menstrual symptoms and other health measures also showed significant improvement, with no reported adverse effects. This study concluded that Shatavari may effectively reduce vasomotor symptoms, menstrual discomfort, and hormonal imbalances, while also improving skin and hair health. Shatavari supplementation therefore demonstrates potential as a safe and natural alternative for perimenopausal symptom management. 

The fifth study reviewed findings on stress-mediated reproductive health disorders in women and the potential role of Shatavari as a treatment option. Research indicated that Shatavari may help hormonal imbalance due to its phytoestrogenic properties, regulating estrous or ovarian cycles while reducing menopausal symptoms. One study reported Shatavari’s potential to alleviate PMS, dysmenorrhoea, and pituitary gland dysfunctions while promoting growth, differentiation, and physiological functions of the female gential tract. One study demonstrated that supplementation with 10mg of Shatavari per day reduced symptoms associated with polycystic ovarian syndrome, a common reproductive health condition often linked to infertility. This review summarized recent findings supporting that Shatavari may benefit female fertility, nourish the ovaries, and enhance the body’s antioxidant capacity to help correct reproductive health disorders. 

Tags: Ayurveda, Herbal medicine, herbal supplementation, hormones, integration of care, menopause, perimenopausal hormonal regulation, Polycystic Ovary System (PCOS), postmenopausal, Premenstrual Syndrome (PMS), reproductive health, Shatavari, traditional medicine, women’s health

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Referenced Research Publications

Frontiers in Reproductive Health
2025, November 26

Efficacy and safety of Shatavari root extract (Asparagus racemosus) for menopausal symptoms: a randomized, double-blind, three-arm, placebo-controlled study.

Abstract

Menopause brings hormonal changes that can significantly affect quality of life. Herbal remedies like Shatavari (Asparagus racemosus Willd.) and Ashwagandha (Withania somnifera L. Dunal) are Ayurvedic herbs traditionally used for hormonal balance and associated stress adaptation. The study evaluated the efficacy and safety of Shatavari root extract (SHT) alone and, in combination with Ashwagandha root extract (ARE-SHT), in women with menopausal symptoms. This was an 8-week, randomized, double-blind, placebo-controlled, multicentric study that enrolled 135 women aged 45–65 years. Participants were randomized into three groups: SHT (n = 45) or an ARE-SHT (n = 45), or a placebo (PL; n = 45). The primary outcome was evaluated by the change in the Menopause Rating Scale (MRS) score at weeks 4 and 8. Secondary outcomes were evaluated by changes in Perceived Stress Scale (PSS) score, Menopause-Specific Quality of Life Questionnaire (MENQOL) score, Profile of Mood States (POMS) score, hot flashes, and mood improvement. The serum hormonal assessments and safety evaluations (liver, renal, and thyroid function) were conducted at week 8. Baseline values were comparable among the groups. Significant improvements in MRS scores were observed in the ARE-SHT group compared to SHT [Week 4 and 8 (p < 0.0001)] and PL [weeks 4 (p = 0.01) and 8 (p < 0.0001)], respectively. MENQOL scores improved numerically by week 8. Esteem-related affect (p = 0.025) and mood improvement (p = 0.008) showed significant changes between the groups. Normal hormonal levels were maintained. Mild adverse events were reported by four participants (loose stools and dizziness in the ARE-SHT group, nausea in the SHT monotherapy group, and headache in the PL group). Shatavari root extract was safe and effective; however, combined with Ashwagandha root extract demonstrated a promising option in managing menopausal symptoms and in enhancing overall health. Future studies with longer duration and larger sample sizes across defined menopausal stages are required to confirm and extend these findings.

Reference

Ademola, J., Ajgaonkar, A., Debnath, T., Debnath, K., & Langade, J. (2025). Efficacy and safety of Shatavari root extract (Asparagus racemosus) for menopausal symptoms: A randomized, double-blind, three-arm, placebo-controlled study. Frontiers in Reproductive Health, 7. https://doi.org/10.3389/frph.2025.1654503

Journal of Nutraceuticals and Health
2024, September 16

Therapeutic potential of Shatavari: a nutraceutical for women's health.

Abstract

Shatavari (Asparagus racemosus) is a medicinal herb central to Ayurveda, known for promoting women’s health through hormonal regulation and reproductive support. Its bioactive compounds, such as steroidal saponins, act as phytoestrogens, helping maintain hormonal balance. Increasingly recognized in natural supplementation, it oers therapeutic potential for conditions related to hormonal health. It is traditionally used to address premenstrual syndrome (PMS), polycystic ovary syndrome (PCOS), and menopausal symptoms. Its adaptogenic properties help manage stress, further supporting hormonal stability. However, broader clinical validation is required to conrm its benets and establish dosage guidelines. This review synthesized ndings on its hormonal eects, reproductive benets, and stress-modulating properties. Various formulations like capsules, powders, and tinctures were evaluated for their therapeutic outcomes. Research shows it regulates menstrual cycles, alleviates menopausal symptoms, improves fertility, and enhances lactation. Its antioxidant properties also mitigate oxidative stress, supporting reproductive health. However, most ndings come from small-scale studies, requiring further research. Variability in formulations and limited clinical trials complicate therapeutic standardization. Pharmacokinetic studies are essential to understand absorption, metabolism, and potential drug interactions. This review aims to bridge traditional knowledge and modern research, highlighting Shatavari’s potential as a nutraceutical and emphasizing the need for further clinical studies for safe integration into healthcare.

Reference

Sarkhel, D. (2026). Therapeutic potential of Shatavari: A nutraceutical for women’s health. Journal of Nutraceuticals and Health. https://doi.org/10.61577/jnh.2023.100009

Journal of Menopausal Medicine
2025, March 12

Ashwagandha and Shatavari Extracts Dose-Dependently Reduce Menopause Symptoms, Vascular Dysfunction, and Bone Resorption in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study

Abstract

Objectives

In this study, we investigate the effects of dietary supplementation with standardized aqueous extracts of shatavari (Asparagus racemosus, Ar), ashwagandha (Withania somnifera, Ws), or their combination on menopausal symptoms, vascular dysfunction, bone turnover, and serum concentrations of inflammatory and oxidative stress markers in postmenopausal women.

Methods

Postmenopausal women aged 40–55 were enrolled in a double-blind randomized study to receive one of six treatments: placebo, Ar 250 mg/500 mg, Ws 250 mg/500 mg, or 500 mg extract combining Ar 250 mg and Ws 250 mg. Primary outcomes were changes in the menopause-specific quality of life (MENQOL) questionnaire, bone mineral density/bone turnover markers (BTMs), and reflection index (RI) after 24 weeks. Secondary outcomes included changes in serum inflammatory and oxidative stress markers, and evaluation of supplement safety and tolerability.

Results

Supplemented groups showed significant dose-dependent decrease MENQOL and RI compared with placebo (P < 0.0001). Women supplemented with Ws or Ar extracts had significantly decreased levels of the BTMs C-terminal telopeptide of type I collagen, bone alkaline phosphatase, and receptor activator of nuclear factor kappa-B ligand, and increased osteoprotegerin levels (P < 0.0001). Significantly decreased levels of inflammatory and oxidative stress markers high-sensitivity C-reactive protein and malondialdehyde, and increased glutathione and nitric oxide levels (P < 0.0001) were also observed.

Conclusions

Daily supplementation with Ws or Ar extracts dose-dependently reduces menopausal symptoms, vascular dysfunction, bone turnover/resorption, and estrogen deficiency-related inflammation and oxidative stress in postmenopausal women.

Reference

Pingali, U., Nutalapati, C., & Wang, Y. (2025). Ashwagandha and shatavari extracts dose-dependently reduce menopause symptoms, vascular dysfunction, and bone resorption in postmenopausal women: A randomized, double-blind, placebo-controlled study. Journal of Menopausal Medicine, 31(1), 21. https://doi.org/10.6118/jmm.24025

Journal of the American Nutrition Association
2025, May 28

A Standardized Asparagus Racemosus Root Extract Improves Hormonal Balance and Menstrual Health and Reduces Vasomotor Symptoms in Perimenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study

Abstract

Background

Perimenopausal women often experience dysmenorrhea, menstrual cramps, hormonal imbalances and vasomotor symptoms (VMS), significantly affecting their quality of life. In Ayurveda, Asparagus racemosus (Shatavari) root extract has been used for female reproductive health. This study evaluated the safety and efficacy of CL22205, a standardized A. racemosus root extract, in managing perimenopausal symptoms.

Methods

This randomized, double-blind, placebo-controlled trial was conducted on 50 perimenopausal women (age: 40–50 years) experiencing mild to moderate climacteric symptoms. Participants received either CL22205 (200 mg/day) or placebo over a period of 120 consecutive days. Primary outcome measure was Menopausal Rating Scale (MRS) scores. Secondary measures assessed Hot Flash Weekly Weighted Score (HFWWS), Menstrual Symptom Questionnaire (MSQ), ovarian follicular number using ultrasonography, serum Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), Anti-Müllerian Hormone (AMH), and 17β-Estradiol (E2), skin and hair quality, and patient satisfaction using Integrative Medicine Patient Satisfaction & Outcome Scales (IMPSS & IMOS). Serum biochemistry, hematology, and urine analysis were performed for safety evaluation.

Results

CL22205 significantly reduced (p < 0.001) total MRS scores and HFWWS vs. placebo and baseline after 120 days of treatment, menstrual symptoms (congestive and spasmodic dysmenorrhea) were improved (p < 0.001). CL22205 decreased serum FSH (56.3%), LH (34.3%), and increased AMH (188.1%, p < 0.001) levels. Skin and hair quality improved significantly (p < 0.001), with no adverse events.

Conclusion

CL22205 effectively reduces VMS, menstrual discomfort, and hormonal imbalances while improving skin and hair health, offering a safe and natural alternative for perimenopausal symptoms management.

Reference

Yadav, P., Yadav, S., Vedururu, S. S., & Kumari, G. (2025). A standardized asparagus racemosus root extract improves hormonal balance and menstrual health and reduces vasomotor symptoms in perimenopausal women: A randomized, double-blind, placebo-controlled study. Journal of the American Nutrition Association, 44(8), 754–764. https://doi.org/10.1080/27697061.2025.2510474

Biomedicine and Pharmacotherapy
2018, April 7

Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus)

Abstract

Stress is deeply rooted in the society and women are frequently exposed to psychological, physical and physiological stressors. Psychological stress disturbs reproductive health by inducing generation of reactive oxygen species (ROS) and thereby oxidative stress (OS). The increased OS may affect physiology of ovary, oocyte quality and cause female reproductive health disorders. To overcome stress-mediated reproductive health disorders in women, shatavari (Asparagus racemosus) is frequently recommended in Ayurvedic system of medicine. Although shatavari is one of the major health tonics and most popular rasayana drugs to treat reproductive ailments of women, underlying mechanism of shatavari action at the level of ovary remains poorly understood. Based on the existing studies, we propose that shatavari may improve female reproductive health complications including hormonal imbalance, polycystic ovarian syndrome (PCOS), follicular growth and development, oocyte quality and infertility possibly by reducing OS level and increasing antioxidants level in the body. Further studies are required to elucidate the mechanism of shatavari actions at the level of ovary and oocyte that directly impacts the reproductive health of women.

Reference

Pandey, A. K., Gupta, A., Tiwari, M., Prasad, S., Pandey, A. N., Yadav, P. K., Sharma, A., Sahu, K., Asrafuzzaman, S., Vengayil, D. T., Shrivastav, T. G., & Chaube, S. K. (2018). Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus). Biomedicine & Pharmacotherapy, 103, 46–49. https://doi.org/10.1016/j.biopha.2018.04.003