CTM Curated Research

Five-Elements Music Therapy Clinical Outcomes Review

Research has consistently indicated that Five-Elements Music Therapy from Traditional Chinese Medicine can help alleviate anxiety and depression. This therapy draws on Five Element theory to map musical elements onto emotional processes, facilitating whole-system regulation. When delivered alongside standard care, it is associated with reduced stress, improved emotional symptoms, and increased patient engagement, positioning it within integrative care models that address psychosocial and physiological aspects of illness. The following studies have shown promising outcomes across oncology, perioperative, and chronic disease settings, suggesting a pattern of psychosocial regulation; however, the results remain underspecified.

A group of people sitting on top of a wooden box.
A group of people sitting on top of a wooden box. Photo by Alvaro Palacios on Unsplash.

The First study conducted a retrospective comparative analysis of 78 patients with diffuse large B-cell lymphoma who received standard care plus Five-Element Music Therapy and mindfulness meditation. Those who received the combined practice/therapy showed reduced fatigue, anxiety, and depression, as well as better sleep, greater engagement with treatment, and improved overall quality of life, with evidence suggesting multiple interconnected pathways in which intervention at one dimension creates beneficial changes that cascade across multiple physiological domains.

The second study conducted a hospital-based comparative analysis involving 460 patients with lung cancer who received Five-Element Music therapy alongside conventional nursing care, compared to conventional nursing care alone. They showed a significantly greater reduction in cancer-related fatigue, anxiety/depression levels, and improved behavioral, physical, emotional, and cognitive status. Logistic regression indicates that improvements in mood may be associated with increased treatment adherence, supporting this therapy as an effective adjunct for managing symptoms and psychosocial well-being.

The Third study employed a retrospective comparative analysis of patients undergoing surgery and receiving Five-Element Music Therapy alongside routine traditional nursing care. For preoperative patients, they found that, compared to routine care alone, the patients receiving Five-Element Music Therapy showed significant improvements in quality of sleep and a reduction in pain and anxiety. However, subsequent findings indicate short-term stabilization, suggesting that the effects were not sustained beyond the immediate perioperative period.The fourth study was a retrospective study of 156 hospitalized patients with a diagnosis of decompensated liver cirrhosis. They compared the effects of those receiving Five Element Music Therapy in combination with Traditional Chinese Medicine rehabilitation care against those receiving rehabilitation alone. The findings indicate improvements in anxiety, depression levels, and sleep quality, and various nutritional indicators, while no significant between-group differences were observed in liver function outcomes.

Tags: Five-Elements Music Therapy, integrative oncology, mind–body intervention, psychosocial symptom management, Traditional Chinese Medicine (TCM)

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Referenced Research Publications

Noise & Health
2025, November 1

Reference

Chen, T., Niu, H., & Wang, Y. (2025). Efficacy of the Five-Element Music Therapy Combined with Mindfulness Meditation on the Fatigue, Anxiety and Depression of Diffuse Large B-Cell Lymphoma Patients Who Are Undergoing Chemotherapy. Noise & health, 27(129), 863–871. https://doi.org/10.4103/nah.nah_145_25

Noise & Health
2025, November 1

Reference

Liu, H., Xia, G., Zhang, Q., Liang, S., & Mo, M. (2025). Effects of Five-Element Music on Cancer-Related Fatigue and Negative Emotion in Patients with Lung Cancer. Noise & health, 27(129), 811–818. https://doi.org/10.4103/nah.nah_153_25

Noise & Health
2024, July 1

Reference

Ren, Z., & Xue, Y. (2024). Effects of Five-Element Music Stimulation in Perioperative Period on Sleep Status and Psychological Regulation in Patients Undergoing Orthopedic Surgery. Noise & health, 26(122), 403–409. https://doi.org/10.4103/nah.nah_77_24

Noise & Health
2026, January 1

Reference

Jiang, L., Zhang, L., Chen, S., & Wang, Y. (2026). Effects of Five-Element Music Therapy Combined with Traditional Chinese Medicine Rehabilitation on Clinical Outcomes in Decompensated Liver Cirrhosis. Noise & health, 28(130), 72–81. https://doi.org/10.4103/nah.nah_169_25

Frontiers in Psychology
2025, September 28

Reference

Lyu, P., Li, X., & Yao, X. (2025). An empirical study on the intervention of traditional Chinese medicine five-element music in alleviating anxiety and depression among medical students: differences in effectiveness among three different musical instruments. Frontiers in psychology, 16, 1625325. https://doi.org/10.3389/fpsyg.2025.1625325